ASP1 — Schizosaccharomyces pombe 972h-

Summary

SPAC977.12 (ASP1) in Schizosaccharomyces pombe encodes a probable L-asparaginase 2, a member of the asparaginase/glutaminase family with asparaginase activity (EC 3.5.1.1). The gene is associated with asparagine breakdown, cell quiescence, chromosome biorientation, mitochondrion distribution, polyphosphate metabolism, iron-sulfur cluster assembly, the spindle assembly checkpoint, polar cell growth, and cell morphogenesis. It localises to the cytoplasm and periplasm. Phenotypic associations link ASP1 to abnormal flocculation, biofilm formation, adhesion, colony shape, invasive growth, pseudohyphal growth, cell wall morphology, respiratory metabolism, cell cycle progression in G1 phase, fermentative and anaerobic growth, carbon source utilisation, thermotolerance, stress resistance, and increased replicative lifespan. Studies of related genes in other species connect the family to filamentous growth and UV resistance.