ase1 — Schizosaccharomyces pombe 972h-

Summary

SPAPB1A10.09 (ase1) in Schizosaccharomyces pombe 972h- on chromosome 1 encodes a microtubule-binding protein of the MAP65_Ase1_PRC1 family. The protein binds microtubules laterally and is associated with spindle midzone assembly, meiotic and mitotic spindle elongation, microtubule bundling, and negative regulation of plus-end-directed microtubule sliding. It is associated with septum positioning, spindle orientation, nuclear migration via microtubule-mediated pushing forces, and the mitotic cytokinesis checkpoint. The product localizes to mitotic and meiotic spindle microtubules, the spindle midzone, cortical microtubules, and the microtubule cytoskeleton. Associations with horsetail-astral microtubule organization, metaphase spindle stability, and protein positioning further link ase1 to fundamental cytoskeletal processes governing cell division and chromosome segregation.