eme1 — Schizosaccharomyces pombe 972h-

Summary

SPAPB1E7.06C (eme1) in Schizosaccharomyces pombe 972h- encodes a protein of the Mms4/EME1/EME2 family, containing an ERCC4 domain and XPF_nuclease_EME1_ascomycetes domain. The gene product binds DNA and metal ions. Eme1 is associated with resolution of recombination intermediates, meiotic joint molecule formation, strand invasion, and recombinational repair. It is linked to replication fork arrest and processing, the DNA replication checkpoint, intra-S DNA damage checkpoint, and response to hydroxyurea. The protein localises to the resolvasome and nuclear replication fork. Additional associations include gene conversion, mating type switching, base excision repair, sumoylation, mitotic and reciprocal meiotic recombination, kinetochore assembly, and G2 phase.