FBP1 — Schizosaccharomyces pombe 972h-

Summary

SPBC1198.14C (FBP1) on chromosome 2 of Schizosaccharomyces pombe 972h- encodes fructose-1,6-bisphosphatase (EC 3.1.3.11), a class-1 FBPase with that hydrolyses fructose 1,6-bisphosphate to fructose 6-phosphate. The enzyme is localised in the cytoplasm, cytosol and nucleus. FBP1 is associated with glucose detection and its regulation, catabolite repression, the glyoxylate cycle, fructose metabolism, adenylyl cyclase activation, uracil and sucrose anabolism, cell integrity MAPK cascade, kinetochore assembly, , and cell division regulation. The gene is linked to oxidative stress response, and to phenotypes including abnormal meiosis, increased entry into G0, increased respiratory metabolism, , increased hydrostatic pressure resistance, decreased nitrogen source utilisation, and abnormal colony shape, endocytosis, nuclear transport and silencing.