HIS5 — Schizosaccharomyces pombe 972h-

Summary

SPBC11B10.02C (HIS5) on chromosome 2 of Schizosaccharomyces pombe encodes a histidinol-phosphate transaminase (EC 2.6.1.9) with pyridoxal phosphate binding activity, placing it in the aminotransferase class I/II family. The gene is associated with histidine anabolism and amino acid anabolism, as well as cell cycle processes including mitosis, spindle assembly, nuclear division, homologous recombination, gene conversion, and plasmid recombination. It has also been linked to translation initiation, secretion, protein transport, and cytosol localisation. Phenotypic associations include increased stress resistance, metal resistance, replicative and chronological lifespan, competitive fitness, and altered mitochondrial transport, pexophagy, reticulophagy, mitophagy, respiratory growth, starvation resistance, nitrogen utilisation, and chemical compound accumulation. Studies of related genes in other species link the family to oxidative stress response, mitotic recombination, endocytosis, auxotrophy, and vacuolar morphology.