pck2 — Schizosaccharomyces pombe 972h-

Summary

SPBC12D12.04C (pck2) on chromosome 2 of Schizosaccharomyces pombe 972h- encodes a protein kinase C (PKC) with novel protein kinase C activity, classified as EC 2.7.11.13, and possesses domains including C2, HR1, and a protein kinase domain. It exhibits protein serine/threonine kinase activity, ATP binding, and lipid binding. The gene is associated with the positive regulation of the cell integrity MAPK cascade, mitotic cytokinesis site selection, and cytoplasmic mRNA processing body assembly. It is linked to alpha-glucan and beta-D-glucan biosynthetic processes, cell wall regulation, response to glucose, and cell shape determination. The product localizes to the actomyosin contractile ring, division septum, cell tips, and stress granules. Studies of related genes in other species link the family to pathogenicity, though this is not established for pck2 in S. pombe.