PHOD — Schizosaccharomyces pombe 972h-

Summary

SPBC1683.01 (PHOD) on chromosome 2 of Schizosaccharomyces pombe encodes a phosphate permease belonging to the major facilitator superfamily (MFS) of sugar transporters. The gene product is associated with multiple transmembrane transporter activities, including those for phosphate, glycerol-3-phosphate, glycerophosphodiester, selenite, and manganese ions, and with phosphate ion binding. PHOD is linked to phosphate homeostasis, polyphosphate metabolism, and responses to nutrient availability. It localizes to the plasma membrane, vacuolar membrane, Golgi membrane, and endoplasmic reticulum. The gene is associated with numerous cellular processes, including cell cycle progression, spore germination, biofilm formation, desiccation resistance, and respiratory metabolism. Studies of related genes in other species link the family to phosphate content and sodium accumulation.