PRP2 — Schizosaccharomyces pombe 972h-

Summary

SPBC16H5.10C (PRP2, also known as prp43) on chromosome 2 of Schizosaccharomyces pombe encodes a DEAH-box RNA helicase with 3'-5' RNA helicase activity, ATP binding and hydrolase activity, and the ability to bind double-stranded RNA, mRNA, and ribosomal small subunits. The gene is associated with spliceosome complex disassembly, catalytic spliceosome formation for both transesterification steps, and mRNA cis splicing via the spliceosome. It is linked to chromosome separation, nuclear division, S phase progression, meiosis, cell cycle control, and positive regulation of transcription by RNA polymerase I. The product localises to the spliceosome, nucleolus, and chromatin. Phenotypic associations include abnormal carbon source utilisation, delayed chromosome segregation, increased X-ray resistance, altered mating efficiency, and defects in cell cycle progression through G2/M and S phases.