tea4 — Schizosaccharomyces pombe 972h-

Summary

SPBC1706.01 (tea4) on chromosome 2 of Schizosaccharomyces pombe encodes a protein containing a polarity/bud-selection regulatory domain and an SH3 domain, and functions as a cytoskeletal adaptor. It is associated with the establishment and maintenance of bipolar cell polarity, monopolar cell growth, and polar cell growth, as well as with actin polymerization and the establishment or maintenance of actin cytoskeleton polarity. The gene is linked to microtubule dynamics, including stabilization, destabilization, and shortening, and localizes to microtubule plus-ends, the cortical microtubule plus-end, cell tips, and the cell division site. Tea4 is also associated with cell size control, the G2 phase, the MAPK cascade, response to nutrients, and cytoplasmic streaming. Related genes in other species encode SH3 domain-containing proteins.