MES1 — Schizosaccharomyces pombe 972h-

Summary

SPBC17A3.04C (MES1, rar1) on chromosome 2 of Schizosaccharomyces pombe 972h- encodes a methionine-tRNA ligase (EC 6.1.1.10) with methionine-tRNA ligase activity and ATP binding, belonging to the methionyl/leucyl-tRNA synthase family. The gene is associated with methionyl-tRNA aminoacylation, meiosis I/II transition, meiotic exit, second meiotic division, kinetochore assembly, prophase, metaphase, anaphase, nuclear division, sister chromatid cohesion, protein ubiquitination, adenylyl cyclase activation, glucose effect, mitotic exit, and DNA anabolism. It localises to the cytosol, mitochondria, mitochondrial lumen, stress granules, and multisynthetase complexes. Phenotypic associations include increased critical cell size at the G1 checkpoint, cell cycle arrest at start, increased pseudohyphal growth, abnormal sporulation, decreased viability, increased cold sensitivity, increased thermotolerance, increased stress resistance, decreased telomere length, decreased fermentative and respiratory growth, and altered transposable element transposition.