DO — Schizosaccharomyces pombe 972h-

Summary

SPBC19G7.05C (DO, also known as FKS1, GSC1, or bgs1) on chromosome 2 of Schizosaccharomyces pombe encodes a protein with Glyco_trans_48, FKS1-like_dom2, and FKS1-like_dom1 domains, possessing branched 1,3-beta-D-glucan synthase, callose synthase, and a-1,3-glucan synthase activities (EC 2.4.1.34). The gene is associated with fungal-type cell wall polysaccharide biosynthesis, particularly 1,3-beta-glucan and ascospore wall glucan anabolism. It is linked to cell division processes including primary and secondary cell septum biogenesis, cleavage furrow formation, contractile ring contraction, midbody abscission, and microtubule nucleation. The product localizes to the primary cell septum, cleavage furrow, mitotic actomyosin contractile ring, spore wall, and growing cell tips. Phenotypic associations include abnormal shmoo formation, decreased spore germination rate, absent alkaline pH resistance, decreased adhesion, altered cell cycle progression through G2/M, and delayed pexophagy. Studies of related genes in other species link the family to beta-glucan content, sporogenesis, and oxidative stress response.