byr2 — Schizosaccharomyces pombe 972h-

Summary

SPBC1D7.05 (byr2) on chromosome 2 of Schizosaccharomyces pombe encodes a protein with a Ras-binding domain, SAM domain, and a serine/threonine kinase domain, exhibiting MEKK activity (EC 2.7.11.25) and protein serine/threonine kinase activity. The gene is associated with sex determination, embryogenesis, G1/G0 transition, energy homeostasis, JNK and p38 cascades, protein kinase A activation, nucleus organization, fruiting body formation, syngamy, meiotic S phase, cell cycle phase, meiotic gene conversion, microtubule dynamics, regulation of mitosis, contractile ring assembly, fungal-type cell wall organization, and response to glucose. It localizes to the division septum, cell tip, cell division site, plasmalemma, cytoplasm, and cytosol. Associations include calcium sensitivity, oxidative stress response, and numerous phenotypes affecting cell cycle progression, mating efficiency, osmotic stress resistance, budding, and pheromone response. Related genes in other species link it to MAPK cascades and pathogenicity traits.