MEC1 — Schizosaccharomyces pombe 972h-

Summary

SPBC216.05 (MEC1, rad3) on chromosome 2 of Schizosaccharomyces pombe encodes a protein serine/threonine kinase with histone H2A kinase activity (EC 2.7.11.1), belonging to the PI3/4_kinase_cat_sf and containing ATR-like M-HEAT, FAT, and FATC_dom. The gene is associated with the DNA integrity checkpoint, DNA damage response signal transduction, regulation of double-strand break repair, response to radiation and UV, mitotic S phase, positive regulation of DNA-templated DNA replication, trans-autophosphorylation, protein kinase A activation, microtubule destabilization, and aggression. It is linked to the ATR-ATRIP Complex and localizes to the nucleus, nucleolus, chromatin, and telomeric regions. Phenotypic associations include abnormal colony size, absent X-ray resistance, altered cell cycle progression rates (increased G1 and S phase, decreased G2, delayed mid-anaphase and telophase), increased thermotolerance, increased sporulation rate, and altered nutrient uptake.