GRX3 — Schizosaccharomyces pombe 972h-

Summary

SPBC26H8.06 (GRX3, grx4) on chromosome 2 of Schizosaccharomyces pombe encodes a monothiol glutaredoxin with disulfide oxidoreductase, glutathione disulfide oxidoreductase, antioxidant, protein-disulfide reductase and protein sequestering activities, and binds 2Fe-2S clusters and metals. The gene is associated with cell redox homeostasis, cellular detoxification of hydrogen peroxide, iron-sulfur cluster assembly (both 2Fe-2S and 4Fe-4S), response to iron, cellular iron ion homeostasis, iron transport, toxic metabolite repair, ER-phagy, nuclear export, and response to stress. It localises to the mitochondrial lumen, mitochondria, cytoplasm, cytosol and nucleus. Phenotypic associations include abnormal colony colour, delayed or absent pexophagy, decreased nucleus size, S-phase cell cycle arrest, decreased critical cell size at the G1 checkpoint, increased meiotic recombination and mitochondrial rho- mutation frequency, decreased utilization of iron sources, and absent mating response.