atf1 — Schizosaccharomyces pombe 972h-

Summary

SPBC29B5.01 (atf1) on chromosome 2 of Schizosaccharomyces pombe encodes a bZIP transcription factor with DNA-binding transcription activator activity specific to RNA polymerase II. It also exhibits recombination hotspot binding, nucleosome binding, and chromatin adaptor functions. Atf1 is associated with responses to salt, UV, amino acid starvation, and hydrostatic pressure, as well as with calcium and acid sensitivity. The gene is linked to the SAPK signaling pathway, activation of reciprocal meiotic recombination, mRNA destabilization, and posttranscriptional regulation of gene expression. It localizes to the nucleus, chromatin, and heterochromatin, and forms the Atf1-Pcr1 complex. Studies of related genes in other species link the family to reduced virulence and unaffected pathogenicity.