MYO2 — Schizosaccharomyces pombe 972h-

Summary

SPBC2D10.14C (MYO2, myo51) on chromosome 2 of Schizosaccharomyces pombe encodes a myosin V motor protein with calcium-dependent ATPase activity, microfilament motor activity, calmodulin binding, F-actin binding, and small GTPase binding. This gene is associated with actin filament bundle retrograde transport, vesicle transport along actin filaments, actomyosin contractile ring assembly, formin-nucleated actin cable assembly, spindle pole body separation, centromere separation, Golgi division, abscission, organelle inheritance, peroxisome inheritance, nuclear migration during mitotic telophase, spindle orientation and breakdown, and endomembrane organization. It localizes to the myosin V complex, LINC complex, formin-nucleated actin cables, cortical cytoskeleton, transport vesicles, and gamma-tubulin ring complex. Phenotypic associations include delayed nuclear fusion during mating, absent or decreased septum formation, increased mating type switching, decreased cytokinesis, absent peroxisomal transport, abnormal Golgi and endoplasmic reticulum distribution, and abnormal prion inheritance.