BUB1 — Schizosaccharomyces pombe 972h-

Summary

SPBC32F12.02 (BUB1, rec14) on chromosome 2 encodes a WD40-repeat protein with DNA-binding transcription repressor activity, mediator complex binding, histone deacetylase binding, and ubiquitin ligase substrate adaptor function. The gene is associated with mitotic spindle checkpoint, metaphase chromosome alignment, MCC assembly, regulation of chromosome segregation, meiotic sister chromatid cohesion, spindle orientation, microtubule dynamics, and centromere localization. It is linked to negative regulation of isoprenoid metabolism and fatty acid anabolism, as well as regulation of mitosis and chromosome condensation. The protein localizes to the Ski complex, transcription repressor complex, SAGA complex, SCF complex, microtubule-associated complex, and spindle pole. Phenotypic associations include altered cell cycle progression through G1/S, G2/M, and metaphase-anaphase transitions, premature meiosis, increased sporulation, delayed chromosome segregation, and decreased chemical resistance. Related genes in other species link it to acid sensitivity and oxidative stress response.