GAP1 — Schizosaccharomyces pombe 972h-

Summary

SPBC359.01 (GAP1) on chromosome 2 of Schizosaccharomyces pombe encodes an amino-acid permease with L-arginine and L-lysine transporter activity. The gene is associated with basic amino acid transport, including L-lysine, L-leucine, and L-arginine import into cells, as well as cell-cell fusion, regulation of growth, cytokinesis, and nitrogen utilization. It is linked to numerous phenotypes, including altered nutrient uptake, cell cycle progression, endocytosis, sporulation, adhesion, and stress responses. The encoded protein localizes to the plasma membrane at cell tips, medial membrane bands, Golgi, ER, and vacuoles. Studies of related genes in other species connect the family to phosphate content and oxidative stress response, though these associations are not established for SpGAP1 itself.