ARK1 — Schizosaccharomyces pombe 972h-

Summary

SPBC36.02C (ARK1) in Schizosaccharomyces pombe 972h- on chromosome 2 encodes a member of the major facilitator superfamily (MFS) of transporters, with annotated xenobiotic, spermidine, spermine and transmembrane transporter activities. The gene is associated with diverse biological processes including regulation of chromosome segregation, centrosome duplication, putrescine and peptide transport, galactose-specific flocculation, fluconazole transport, TORC2 signaling, kinetochore assembly, and microtubule shortening. It is linked to cell cycle progression, particularly delayed G2 phase and arrested S phase, as well as decreased cytokinesis, endocytosis, and resistance to chemicals. Additional associations include abnormal filamentous and pseudohyphal growth, decreased mating-type switching, increased polyploidy, and altered prion state. The encoded protein localizes to the cellular bud membrane, fungal-type vacuole and its membrane, Golgi complex, endoplasmic reticulum, and plasmalemma.