hhp1 — Schizosaccharomyces pombe 972h-

Summary

SPBC3H7.15 (hhp1) on chromosome 2 of Schizosaccharomyces pombe encodes a casein kinase I family member with protein serine/threonine kinase activity (EC 2.7.11.1), also annotated with protein tyrosine kinase activity, ATP binding, magnesium binding, and identical protein binding. The gene is associated with regulation of DNA metabolism, DNA repair, double-strand break repair, homologous chromosome segregation, meiotic sister chromatid arm separation, spindle attachment to the meiosis I kinetochore, and linear element assembly. It is linked to positive regulation of filamentous growth, clathrin-mediated endocytosis, and cell differentiation, as well as negative regulation of ergosterol biosynthesis. Localisation evidence connects the product to the spindle pole body, monopolin complex, preribosome, vacuolar lumen, P body, and growing cell tip. Phenotypic associations include delayed vegetative and respiratory growth, increased sporulation, abnormal spore germination, altered cell cycle progression, and absent peroxisomal transport.