OS-5 — Schizosaccharomyces pombe 972h-

Summary

SPBC409.07C (wis1, OS-5) in Schizosaccharomyces pombe encodes a dual-specificity protein kinase with MAPKK activity (EC 2.7.12.2), also annotated with MAP kinase scaffold activity, Nalpha-acetyltransferase activity, and protein serine/threonine kinase activity. The gene is associated with stress-activated MAPK cascades, including the p38 cascade and osmosensory signaling via the Sho1 osmosensor, as well as pheromone response, filamentous growth, glucose detection, and regulation of ascospore formation. It is linked to glycerol anabolism, response to arsenic, mRNA destabilization, and positive regulation of chromatin silencing. Phenotypic associations include absent mating efficiency, increased acquired thermotolerance, increased fermentative growth, increased sporulation rate, and increased pexophagy, alongside abnormal carbon source utilization and cell cycle progression defects. The product localizes to the NatB complex, Mcs4 RR-MAPKKK complex, cell tips, bud neck, and division septum. Studies of related genes in other species link the family to turgor pressure, salt tolerance, calcium sensitivity, and loss of pathogenicity.