GAP1 — Schizosaccharomyces pombe 972h-

Summary

SPBC460.01C (GAP1) in Schizosaccharomyces pombe encodes a plasma membrane amino acid transmembrane transporter belonging to the APC/YAT family. The gene product has L-arginine and L-lysine transporter activity and is associated with the transport of basic amino acids, including L-lysine, L-arginine, and L-leucine import into cells. GAP1 is linked to cell-cell fusion, regulation of growth, Ras protein signal transduction, replication fork arrest, cytokinesis regulation, nucleosome assembly, and cellular stress response. It localizes to the plasma membrane at cell tips, the medial membrane band, and the cell division site. Phenotypic associations include altered nutrient uptake, cell cycle progression, endocytosis, sporulation, spore germination, replicative lifespan, and resistance to hydrostatic pressure. Related genes in other species connect the family to phosphate content and oxidative stress response.