MKK1 — Schizosaccharomyces pombe 972h-

Summary

SPBC543.07, also known as MKK1 or pek1, encodes a mitogen-activated protein kinase kinase (MAPKK) with dual-specificity protein kinase activity, classified under EC 2.7.12.2. This enzyme is associated with multiple MAPK cascades, including the cell integrity and pheromone response pathways, and is linked to the regulation of ascospore formation, morphogenesis, cell wall organization, calcium-mediated signaling, actin depolymerization, and filamentous growth. The gene product localizes to the cell tip, division septum, mating projection tip, cytoplasm, and nucleus. Phenotypic associations include abnormal cell cycle progression through G2/M phase, delayed anaphase and telophase, absent sporulation efficiency, absent alkaline pH resistance, abnormal mating response, absent cell fusion, decreased budding, and altered endocytosis and pexophagy. Studies of related genes in other species link the family to oxidative stress response and virulence.