NTH1 — Schizosaccharomyces pombe 972h-

Summary

SPBC660.07, also known as NTH1 or ntp1 on chromosome 2 of Schizosaccharomyces pombe, encodes a trehalase enzyme (EC 3.2.1.28) with alpha,alpha-trehalase activity and calcium ion binding, belonging to the glycoside hydrolase family 37. The gene is associated with mycose catabolism and metabolism, as well as triglyceride anabolism, cellular homeostasis, DNA repair pathways including TC-NER and BER, the MAPK cascade, ascospore formation, sporulation, and responses to heat and starvation. It localises to the cytoplasm and cytosol. The gene is linked to increased acquired thermotolerance and freeze-thaw resistance, altered cell cycle progression including premature metaphase and telophase, increased aneuploidy, and changes in budding patterns, flocculation, and fermentative versus respiratory metabolism. Studies of related genes in other species connect the family to reduced virulence and oxidative stress response.