APG7 — Schizosaccharomyces pombe 972h-

Summary

SPBC6B1.05C (APG7, atg7) on chromosome 2 of Schizosaccharomyces pombe encodes a protein with Atg7_N domains that possesses Atg12 activating enzyme activity, identical protein binding, and ATP hydrolase activity. The gene is associated with macroautophagy, mitophagy, the cytoplasm-to-vacuole targeting (Cvt) pathway, and cellular response to nitrogen starvation. It is linked to mitochondrial translation elongation, spindle elongation, meiotic chromosome segregation, and cell cycle modulation. The product localises to the cytoplasm, nucleus, and phagophore assembly site membrane. Phenotypic associations include abnormal autophagy, absent mitophagy, decreased ribophagy, delayed shmoo formation, increased mitochondrial rho- mutation frequency, decreased colony size, and abnormal carbon source utilisation.