BUD30 — Schizosaccharomyces pombe 972h-

Summary

SPBC646.13 (BUD30, sds23) on chromosome 2 of Schizosaccharomyces pombe 972h- encodes a protein with protein serine/threonine phosphatase inhibitor activity and aspartic endopeptidase activity, belonging to the AMPK_gamma/SDS23 family with CBS domains. The gene is associated with glucose homeostasis and response to glucose, regulation of mitotic cytokinesis and the metaphase/anaphase transition, negative regulation of the acetoacetate-mevalonate pathway, sterol homeostasis, flocculation, spindle positioning and elongation, and protein dephosphorylation. It localizes to the cell tip, cytoplasm, cytosol, and nucleus. Associations include abnormal cell cycle progression in metaphase and telophase, altered fermentative and respiratory metabolism, increased osmotic stress resistance, increased apoptosis, abnormal budding and cellular morphology, and absent sporulation. Studies of related genes in other species link the family to abnormal budding patterns and stress resistance.