brc1 — Schizosaccharomyces pombe 972h-

Summary

SPBC582.05C (brc1) on chromosome 2 of Schizosaccharomyces pombe 972h- encodes a chromatin adaptor containing a BRCT domain. The gene product is associated with DNA damage repair and checkpoint pathways, including homologous recombination, non-homologous end joining, base excision repair, nucleotide excision repair, mismatch repair, and DNA damage tolerance. It is linked to replication fork arrest and processing, as well as rDNA maintenance and chromatin organization. Brc1 is also associated with microtubule destabilization, spindle assembly, and the spindle assembly checkpoint. The protein localizes to the nucleus, nucleolus, subtelomere, rDNA heterochromatin, centromere complex, and sites of double-strand breaks, and is part of the Cul8-RING ubiquitin ligase complex. Additionally, it is associated with the response to methyl methanesulfonate and the attachment of double-strand breaks to the nuclear envelope.