sep1 — Schizosaccharomyces pombe 972h-

Summary

SPBC4C3.12 (sep1) on chromosome 2 of Schizosaccharomyces pombe 972h- encodes a forkhead domain-containing transcription factor with both RNA polymerase II-specific DNA-binding transcription repressor and activator activities, and sequence-specific DNA binding. It is associated with regulation of cell division, cell cycle switching between mitotic and meiotic cycles, entry into meiosis, pachytene, prophase, G1, G2, and M phases, interphase, nuclear division, division septum assembly, cell morphogenesis, pseudohyphal growth, and ribosomal protein gene transcription. The protein localizes to chromatin and the nucleus. It has been linked to inflorescence number and germination rate. Studies of related genes in other species connect the family to loss of pathogenicity.