ARK1 — Schizosaccharomyces pombe 972h-

Summary

SPBC530.15C (ARK1) in Schizosaccharomyces pombe encodes a major facilitator superfamily (MFS) transporter with xenobiotic, spermidine, spermine and transmembrane transporter activities. The gene is associated with a wide range of cellular processes including chromosome segregation, centrosome duplication, kinetochore assembly, sister chromatid segregation, chromosome condensation, meiosis II, telophase, microtubule shortening, TORC2 signaling, cellular homeostasis, putrescine and peptide transport, fluconazole transport, galactose-specific flocculation, and protein positioning. It localises to the plasma membrane, Golgi, ER, vacuole and bud membrane. Phenotypic associations include delayed cell cycle progression, decreased cytokinesis and endocytosis, abnormal filamentous and pseudohyphal growth, altered mating-type switching, increased polyploidy, and reduced necrotic cell death. Studies of related genes in other species link the family to reduced virulence.