clr4 — Schizosaccharomyces pombe 972h-

Summary

SPBC428.08C (clr4) on chromosome 2 of Schizosaccharomyces pombe encodes a protein with SET, pre-SET, post-SET and chromodomains, classified as EC 2.1.1.355, 2.1.1.366 and 2.1.1.367. The enzyme has histone H3K9 methylase, monomethylase, dimethylase and trimethylase activities, as well as histone H3K36 methylase activity and ubiquitin-modified histone reader activity. Clr4 is associated with heterochromatin organization, including constitutive heterochromatin assembly, regulation of heterochromatin assembly, RNAi-mediated co-transcriptional gene silencing, and post-transcriptional gene silencing. It is linked to meiotic telomere clustering, centromere clustering, suppression of meiotic recombination, mitotic sister chromatid separation, microtubule destabilization, DNA replication licensing, rDNA maintenance, and memory. The protein localizes to the nucleus, chromatin, centric heterochromatin, subtelomeric heterochromatin, mating-type region heterochromatin, the CLRC complex, and the spindle pole body. Related genes in other species are linked to histone methylation.