wpl1 — Schizosaccharomyces pombe 972h-

Summary

SPBC428.17C (wpl1) on chromosome 2 of Schizosaccharomyces pombe encodes the Wpl1 protein, a member of the WAPL family characterized by a WAPL_C domain and ARM-like repeats. The gene product possesses cohesin unloader activity, ATP-dependent protein binding, ATP hydrolase activity, and DNA binding. Wpl1 is associated with mitotic sister chromatid cohesion, homologous chromosome pairing at meiosis, chromatin looping, and chromosome division. It is linked to prophase, metaphase, anaphase, S phase, interphase, and mitotic exit. The protein localizes to the nucleus and nuclear chromosome, specifically as part of the Wpl/Pds5 cohesin loading/unloading complex. Additional associations include DNA replication, DNA repair, dephosphorylation, methylation, and mating.