mis12 — Schizosaccharomyces pombe 972h-

Summary

SPBC409.04C (mis12) on chromosome 2 of Schizosaccharomyces pombe 972h- encodes the Mis12 protein, a member of the Centromere_Mis12 family. The product localizes to the outer and inner kinetochore, the centromeric core domain, and the nucleus. It is associated with mitotic and meiotic chromosome segregation, kinetochore assembly, spindle attachment to kinetochores, spindle assembly and checkpoint control, sister chromatid cohesion, centromere separation and localization, and microtubule dynamics. The gene is also linked to interphase, prophase, metaphase, and RNA splicing. Related genes in other species link the Mis12 family to the MIND complex.