SKP1 — Schizosaccharomyces pombe 972h-

Summary

SPBC409.05, also known as SKP1 or skp1 in Schizosaccharomyces pombe 972h- on chromosome 2, encodes a protein belonging to the SKP1-like family, which includes the SKP1/BTB/POZ superfamily and is characterized by Skp1 component dimerization and POZ domains. The gene product binds cullin family proteins and glutathione. SKP1 is associated with the SCF-dependent proteasomal ubiquitin-dependent protein breakdown pathway and is linked to numerous cell cycle processes, including mitotic cell cycle control, regulation of DNA recombination, meiotic chromosome segregation, and the downregulation of the mitotic metaphase/anaphase transition. It is associated with cell fate determination, embryogenesis, vacuolar proton-transporting V-type ATPase complex assembly, nuclear envelope organization, and ergosterol metabolism. Phenotypic associations include altered cell cycle progression, decreased flocculation, increased mating efficiency, delayed sporulation, and abnormal meiotic recombination. The protein localizes to the cytoplasm, nucleus, endomembrane system, and the RAVE complex.