SLA2 — Schizosaccharomyces pombe 972h-

Summary

SPBC3B9.11C, also known as SLA2 or ctf1 in Schizosaccharomyces pombe 972h- on chromosome 2, encodes a protein containing RNA recognition motif (RRM) and cleavage stimulation factor (CSTF) domains, and is associated with mRNA binding. This gene is linked to mRNA cleavage and polyadenylation specificity factor complexes, termination of RNA polymerase II transcription, and cotranscriptional 3' processing of mRNA transcripts. It is associated with endocytosis, cell morphogenesis, cell cycle progression, spindle checkpoint function, response to nutrient availability, and degradation of meiosis-specific transcripts. Phenotypic associations include decreased endocytosis rate, delayed cytokinesis and vegetative growth, abnormal sporulation efficiency, increased gamma ray resistance, altered budding patterns, and defects in vacuolar morphology, nuclear transport, and cell fusion. Studies of related genes in other species link the family to acid sensitivity.