MAD1 — Schizosaccharomyces pombe 972h-

Summary

SPBC3D6.04C (MAD1) on chromosome 2 of Schizosaccharomyces pombe encodes a Mad1 family protein with kinetochore adaptor activity. The gene is associated with activation of mitotic cell cycle spindle assembly checkpoint, MCC assembly, mitotic spindle checkpoint, negative regulation of protein import into nucleus during spindle assembly checkpoint, plus-end directed chromosome gliding, spindle orientation, mitotic DNA integrity checkpoint, centromere localization, microtubule dynamics, and actin polymerization. It localizes to the mitotic spindle, kinetochore, nuclear envelope, mitotic spindle pole body, and nucleus. Phenotypic associations include altered cell cycle progression, particularly premature or delayed metaphase-anaphase transitions, abnormal chromosome segregation, increased nuclear size, and abnormal nuclear fusion during mating. The gene is linked to DUO1, SFI1, YBP2, KIP1, and other genes. Studies of related genes in other species connect the family to CIN2, MCM22, CTF3, and CHL4.