SMT3 — Schizosaccharomyces pombe 972h-

Summary

SPBC365.06, also known as SMT3 or pmt3, encodes the SUMO (small ubiquitin-like modifier) protein in Schizosaccharomyces pombe. The product contains a ubiquitin-like domain and a Rad60/SUMO-like domain, and is annotated with molecular functions including E3 protein ligase binding and protein tagging. This gene is associated with the regulation of sumoylation and desumoylation, and has been linked to numerous nuclear processes such as chromosome condensation, centromere clustering, telophase, prophase, DNA condensation, gene conversion, recombinational repair, and the localization of stalled replication forks to the nuclear periphery. It localizes to the nucleus, mitotic spindle pole body, linear element, and septin ring. Phenotypic associations include effects on cell cycle progression through G1/S and M phases, chromosome segregation, meiosis, sporulation, nuclear fusion during mating, mitotic and meiotic recombination, telomere length, and responses to chemicals and anaerobic growth.