PAC1 — Schizosaccharomyces pombe 972h-

Summary

SPBC354.10 (PAC1, also known as def1) on chromosome 2 of Schizosaccharomyces pombe encodes a protein with ubiquitin-binding and DNA-binding activities, containing CUE and DEF1_CUE domains characteristic of a TC-DDR regulator family member. The gene is associated with numerous nuclear processes including DNA replication initiation and imprinting, telomere maintenance, mating-type switching, meiosis II, snRNA metabolism, mRNA and tRNA processing, RNA breakdown, and transcription-coupled nucleotide excision repair (TC-NER). It is linked to cell cycle regulation across multiple phases, with observed phenotypes including G1/S, G2/M, and metaphase-anaphase transition arrest, increased cell cycle duration, absent chromosome segregation, increased polyploidy, and altered sporulation. Additional associations include increased thermotolerance, hydrostatic pressure resistance, absent UV resistance, abnormal mutation frequency, and decreased adhesion. The protein localizes to the nucleus, cytoplasm, cytosol, and telomeric chromosome regions.