NMT1 — Schizosaccharomyces pombe 972h-

Summary

SPBC2G2.11, also known as myr1 or NMT1 in Schizosaccharomyces pombe 972h- on chromosome 2, encodes a glycylpeptide N-tetradecanoyltransferase (EC 2.3.1.97) with N-myristoyltransferase activity, belonging to the acyl-CoA acyltransferase family. The gene is associated with N-terminal peptidyl-glycine N-myristylation, protein localization to the membrane, and nuclear import. It has been linked to diverse biological processes including thiamin transport and metabolism, sucrose metabolism, long-chain fatty acid metabolism, vitamin A and ergothioneine anabolism, hearing, digestion, cell size control, G2 phase, and response to iron. Phenotypic associations include decreased nutrient uptake and utilization, cell cycle arrest at G1/S and G1 phases, decreased osmotic stress resistance, increased sporulation efficiency, abnormal cell shape and colony appearance, and reduced invasive and pseudohyphal growth. Studies of related genes in other species link the family to reduced virulence and decreased replicative lifespan.