MTO1 — Schizosaccharomyces pombe 972h-

Summary

SPBC30B4.06C (MTO1) on chromosome 2 of Schizosaccharomyces pombe encodes a member of the MnmG family of proteins, which possess FAD/NAD-binding domains and exhibit tRNA 5-taurinomethyluridine synthase activity. The gene is associated with mitochondrial tRNA wobble uridine modification and localizes to the mitochondrial lumen. MTO1 is also associated with meiotic telomere clustering, microtubule stabilization and nucleation, spindle orientation, karyogamy, actin polymerization, and nuclear movement. Phenotypic associations link the gene to decreased respiratory growth, sporulation, and endocytosis, as well as increased stress resistance, metal resistance, and replicative lifespan. The gene is also associated with abnormal mitochondrial genome maintenance, decreased mitophagy and pexophagy, and altered protein content. Studies of related genes in other species connect the family to abnormal respiratory metabolism and decreased chronological lifespan.