ste11 — Schizosaccharomyces pombe 972h-

Summary

SPBC32C12.02 (ste11) on chromosome 2 of Schizosaccharomyces pombe 972h- encodes an HMG-box transcription factor of the SOX family, with sequence-specific DNA-binding and bending activities, and functions as both a transcriptional repressor and activator of RNA polymerase II. This gene is associated with mating type determination, meiotic cell cycle regulation, G1/G0 transition, syngamy, fruiting body formation, embryogenesis, energy homeostasis, and response to glucose. It is also linked to protein kinase A activation, nucleus organization, meiotic gene conversion, and nuclear transport. The product localises to the nucleus, nucleoplasm, chromatin, cytoplasm, cytosol, the spindle pole body, and the RNA polymerase II transcription regulator complex. Additionally, ste11 is associated with calcium sensitivity and oxidative stress response. Related genes in other species link the family to the Tor2-Mei2-Ste11 complex.