SMC1 — Schizosaccharomyces pombe 972h-

Summary

SPBC29A10.04, also known as psm1 or SMC1 in Schizosaccharomyces pombe 972h- on chromosome 2, encodes a structural maintenance of chromosomes (SMC) family protein with ATP hydrolase and DNA translocase activities, binding DNA, chromatin and ATP. The gene is associated with sister chromatid cohesion during both mitosis and meiosis, chromosome condensation and segregation, chromatin looping, and meiotic progression through diplotene and metaphase I. It localises to the mitotic and meiotic cohesin complexes, the condensin complex, condensed chromosomes, centromeric regions, kinetochores and euchromatin. Phenotypic associations link psm1 to abnormal cell cycle progression, including arrest at G2, metaphase-anaphase transition, anaphase and telophase, as well as defective meiosis, sporulation, chromosome segregation, nuclear fusion, cell fusion, chitin deposition, spore wall formation, and altered radiation resistance and telomere length. Studies of related genes in other species connect it to the cohesin complex and regulators such as REC8, SCC2 and ECO1.