BML — Schizosaccharomyces pombe 972h-

Summary

SPBC26H8.07C (nda3, also known as BML) on chromosome 2 of Schizosaccharomyces pombe encodes a beta-tubulin protein that is a structural constituent of the cytoskeleton and possesses GTPase activity with GTP and metal binding. The gene is associated with microtubule dynamics, mitotic spindle pole body duplication, spindle checkpoint function, chromosome condensation and separation, nuclear migration, and mitochondrial positioning. It localizes to astral, spindle, and cytoplasmic microtubules, as well as the cytoplasm, cytosol, and nucleus. Phenotypic associations include abnormal colony size, cell cycle progression delays and arrests in anaphase and metaphase, premature metaphase-anaphase transition, abnormal or absent nuclear fusion during mating, increased polyploidy and aneuploidy, and decreased chromosome segregation. Studies of related genes in other species link the family to cold sensitivity and mitotic cell cycle timing.