rga4 — Schizosaccharomyces pombe 972h-

Summary

SPBC28E12.03 (rga4) on chromosome 2 of Schizosaccharomyces pombe encodes a Rho GTPase-activating protein (Rho-GAP) with a LIM zinc-binding domain, possessing GAP activity, small GTPase binding, lipid binding, and metal binding functions. This gene is associated with the regulation of cell diameter, monopolar and bipolar cell growth, cell polarity establishment, cell wall organization, and actin cytoskeleton organization. It is linked to the negative regulation of the cell integrity MAPK cascade, activation of mitotic division septum assembly, and Golgi-to-plasma membrane protein transport. The product localizes to the cleavage furrow, cellular bud, lateral cell cortex, actomyosin contractile ring, and growing cell tips. Studies of related genes in other species, including rga1, rga2, rga3, and BEM2, connect the family to similar cell polarity and growth processes.