SPBC28F2.12 — Schizosaccharomyces pombe 972h-

Summary

SPBC28F2.12 (rpb1) on chromosome 2 of Schizosaccharomyces pombe encodes a protein with RNA polymerase domains, DNA-directed RNA polymerase activity (EC 2.7.7.6), RNA-directed RNA polymerase activity, chromatin adaptor function, DNA binding, and metal binding. The gene is associated with transcription of mRNA, siRNA, tRNA, and lncRNA, as well as RNA polymerase I and III transcription, mRNA capping, RNAi-like chromatin silencing, regulation of DNA replication and cytokinesis, cell differentiation, and intracellular phosphate homeostasis. It localizes to RNA polymerase I, II, and III complexes, the nucleolus, chromatin, cytosol, and nucleus. Phenotypic associations include abnormal mitophagy, increased transposable element transposition, altered cell cycle progression, increased sporulation and virulence, decreased polyploidy, delayed cytokinesis, and abnormal replicative lifespan. Studies of related genes in other species link the family to acid sensitivity and oxidative stress response.