HST6 — Schizosaccharomyces pombe 972h-

Summary

SPBC25B2.02C (HST6, also known as mam1) in Schizosaccharomyces pombe 972h- on chromosome 2 encodes an ABC-type oligopeptide transporter with ATP hydrolase activity and ATP binding, belonging to the type 1 exporter family. The gene is associated with copulation, peptide pheromone export, conjugation with cellular fusion, sexual reproduction, sporulation, meiosis I and II, meiotic chromosome segregation, sister chromatid cohesion, metaphase and anaphase, cell polarization, pheromone response, MAPK cascade, protein secretion, response to antibiotic, xenobiotic detoxification, and oligopeptide export from mitochondria. It localizes to the plasma membrane, cell tip, cell division site, cortical dynamic polarity patch, fungal-type vacuole, mitochondrial inner membrane, and cytoplasm. Phenotypic associations include absent mating response, abnormal colony shape, decreased fermentative growth, increased aneuploidy, and altered cell cycle progression. Related genes in other species link the family to pheromone export.