CDC7 — Schizosaccharomyces pombe 972h-

Summary

SPBC21C3.18, also known as CDC7 or spo4 in Schizosaccharomyces pombe 972h- on chromosome 2, encodes a protein serine/threonine kinase with ERK1 activity (EC 2.7.11.1) that binds ATP and metal ions. The gene is associated with multiple cell cycle processes including mitotic S phase, pre-RC assembly, positive regulation of DNA replication initiation, centromere separation, meiotic spindle assembly, second meiotic division, spindle breakdown, and cleavage furrow formation. It is linked to upregulation of calcium ion import, calcium-mediated signaling, and DNA repair, as well as downregulation of mitotic cytokinesis. The protein localizes to the cytoplasm, cytosol, nucleus, and DDK complex. Phenotypic associations include altered cell cycle progression rates through G1, G2, and S phases, delayed anaphase, abnormal spore germination, increased sporulation, and arrested meiosis and chromosome segregation.