MAD2 — Schizosaccharomyces pombe 972h-

Summary

SPBC20F10.06, known as MAD2 in Schizosaccharomyces pombe 972h- on chromosome 2, encodes a protein with a HORMA domain and Mad2-like family signature that binds the anaphase-promoting complex (APC). This gene is associated with mitotic and meiotic spindle assembly checkpoints, MCC assembly, chromosome condensation and separation, centromere localization, spindle orientation, microtubule dynamics, and spindle pole body assembly. It localizes to the kinetochore, mitotic spindle microtubule, spindle pole body, nuclear periphery, and chromatin. Phenotypic associations include altered cell cycle progression through anaphase, G1/S and G2/M transitions, premature meiosis, absent sporulation and spore wall formation, decreased colony sectoring, delayed exponential-phase growth, and abnormal pheromone sensitivity. Studies of related genes in other species link the Mad2 family to reduced virulence and turgor pressure.