TOP2 — Schizosaccharomyces pombe 972h-

Summary

SPBC1A4.03C (TOP2) on chromosome 2 of Schizosaccharomyces pombe encodes a DNA topoisomerase type II (EC 5.6.2.2), a member of the TopoIIA family with ATP hydrolase activity, identical protein binding, DNA binding, and metal binding. This gene is associated with chromosome condensation, sister chromatid segregation, chromosome separation, resolution of meiotic recombination intermediates, replication fork progression beyond termination sites, and regulation of sumoylation. It localises to the nucleus, chromatin, euchromatin, and the centromeric core domain. Phenotypically, TOP2 is linked to delayed cell cycle progression in anaphase and telophase, arrested meiosis, increased sporulation, decreased lifespan, absent mating-type switching, increased thermotolerance and gamma ray resistance, and abnormal telomere length. Studies of related genes in other species connect the family to telomere maintenance and DNA repair processes.