bqt4 — Schizosaccharomyces pombe 972h-

Summary

SPBC19C7.10 (bqt4) on chromosome 2 of Schizosaccharomyces pombe 972h- encodes a Bqt4 family protein. The gene product exhibits telomere-nuclear envelope anchor activity, phosphatidate binding, phase separation nucleator activity, lipid binding, and DNA binding. It is associated with chromosome attachment to the nuclear envelope, meiotic and mitotic telomere tethering at the nuclear periphery, meiotic telomere clustering, nuclear membrane biogenesis and organization, regulation of membrane lipid distribution, and nucleus organization. Additional associations include kinetochore clustering at the old mitotic spindle pole body, Golgi localization, adiposome formation, and regulation of lipogenesis. The protein localizes to the nuclear inner membrane, nuclear membrane, nuclear envelope, membrane, cytoplasm, and nucleus. Studies of related genes in other species link the family to the nuclear membrane complex Bqt3-Bqt4.