SRBA — Schizosaccharomyces pombe 972h-

Summary

SPBC19C2.09 (symbol SRBA, preferred name sre1) on chromosome 2 of Schizosaccharomyces pombe 972h- encodes a basic helix-loop-helix (bHLH) domain-containing transcription activator that binds SRE sequences, DNA, and RNA polymerase II cis-regulatory regions, and mediates protein dimerization. This gene is associated with sterol and cholesterol homeostasis, including responses to sterol depletion, oxygen levels, and hypoxia, as well as regulation of ergosterol biosynthesis, cholesterol and glycerophospholipid anabolism, and unsaturated fatty acid anabolism. It is also linked to circadian rhythm, filamentous growth regulation in response to chemical and pH stimuli, symbiotic interactions, and cellular responses to copper. The encoded protein localizes to the Sre1-Scp1 complex, endoplasmic reticulum membrane, nuclear envelope, Golgi membrane, chromatin, cytoplasm, and nucleus. Studies of related genes in other species link the family to reduced virulence and associations with pulmonary aspergillosis and disseminated candidiasis.